CMap Candidate Details

Structure:
CMap ID: C17152
Pert ID: BRD-K46212057
Compound Name: voriconazole
Targets: CYP2C19; CYP2C9; CYP3A4; CYP3A5; PTGS1
MoA: Cytochrome P450 inhibitor
SMILES: C[C@@H](c1ncncc1F)[C@@](O)(Cn1cncn1)c1ccc(F)cc1F
InchiKey: BCEHBSKCWLPMDN-QFYYESIMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34113 BRD-K46212057 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34371 BRD-K46212057 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34629 BRD-K46212057 HCC515 10 uM 6 h -0.22 -0.92 0.06 0.28 1.01 0.44
34894 BRD-K46212057 HEPG2 10 uM 6 h -0.3 -1.24 0.64 0.0 0.0 0.0
35154 BRD-K46212057 HT29 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.58
35322 BRD-K46212057 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35572 BRD-K46212057 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35789 BRD-K46212057 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
35965 BRD-K46212057 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36273 BRD-K46212057 PHH 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
36571 BRD-K46212057 SKB 10 uM 24 h -0.26 -1.08 0.31 -0.3 -1.01 0.58
36971 BRD-K46212057 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96146 BRD-K46212057 A549 10 uM 24 h -0.25 -1.02 0.18 -0.21 -0.71 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).