CMap Candidate Details

Structure:
CMap ID: C17169
Pert ID: BRD-K46290096
Compound Name: preladenant
Targets: ADORA2A
MoA: Adenosine receptor antagonist
SMILES: COCCOc1ccc(cc1)N1CCN(CCn2ncc3c2nc(N)n2nc(nc32)-c2ccco2)CC1
InchiKey: DTYWJKSSUANMHD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125235 BRD-K46290096 A375 10 uM 24 h -0.25 -1.06 0.25 -0.31 -1.06 0.72
125302 BRD-K46290096 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125437 BRD-K46290096 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
125491 BRD-K46290096 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133359 BRD-K46290096 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133383 BRD-K46290096 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133412 BRD-K46290096 HELA 0.01 uM 24 h 0.22 0.93 0.05 -0.22 -0.75 0.06
133447 BRD-K46290096 HT29 0.03 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
133477 BRD-K46290096 JURKAT 0.25 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
133508 BRD-K46290096 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133545 BRD-K46290096 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133601 BRD-K46290096 THP1 2.22 uM 24 h -0.22 -0.93 0.07 -0.27 -0.91 0.29
133623 BRD-K46290096 YAPC 2.22 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).