CMap Candidate Details

Structure:
CMap ID: C01717
Pert ID: BRD-A70461345
Compound Name: naloxone
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor antagonist
SMILES: Oc1ccc2C[C@H]3N(CC=C)CC[C@]4(C5Oc1c24)[C@@]3(O)CCC5=O
InchiKey: UZHSEJADLWPNLE-OGLQFSJHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2970 BRD-A70461345 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3321 BRD-A70461345 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3587 BRD-A70461345 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3699 BRD-A70461345 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44258 BRD-A70461345 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44489 BRD-A70461345 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44783 BRD-A70461345 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45103 BRD-A70461345 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45375 BRD-A70461345 HT29 10 uM 6 h 0.19 0.77 0.0 0.0 0.0 0.0
45621 BRD-A70461345 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45903 BRD-A70461345 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46219 BRD-A70461345 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46534 BRD-A70461345 SKB 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).