CMap Candidate Details

Structure:
CMap ID: C17203
Pert ID: BRD-K46386702
Compound Name: ARRY-334543
Targets: EGFR; ERBB2
MoA: EGFR inhibitor
SMILES: C[C@@H]1COC(Nc2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)=N1
InchiKey: UWXSAYUXVSFDBQ-CYBMUJFWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124569 BRD-K46386702 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124593 BRD-K46386702 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124608 BRD-K46386702 HA1E 10 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
124635 BRD-K46386702 HEK293 0.125 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
124650 BRD-K46386702 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124681 BRD-K46386702 HT29 10 uM 24 h 0.19 0.79 0.0 0.35 1.22 1.15
124738 BRD-K46386702 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124753 BRD-K46386702 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124782 BRD-K46386702 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124826 BRD-K46386702 PC3 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
124870 BRD-K46386702 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
124907 BRD-K46386702 YAPC 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
132826 BRD-K46386702 JURKAT 0.25 uM 24 h -0.2 -0.83 0.0 -0.26 -0.88 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).