CMap Candidate Details

Structure:
CMap ID: C17212
Pert ID: BRD-K46419649
Compound Name: U-0126
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor
SMILES: NC(=C(C#N)C(=C(N)Sc1ccccc1N)C#N)Sc2ccccc2N
InchiKey: DVEXZJFMOKTQEZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3030 BRD-K46419649 HA1E 10 uM 6 h -0.24 -0.99 0.14 0.38 1.33 1.72
3211 BRD-K46419649 HCC515 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
3510 BRD-K46419649 PC3 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
3809 BRD-K46419649 VCAP 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
44405 BRD-K46419649 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44709 BRD-K46419649 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44970 BRD-K46419649 ASC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
45265 BRD-K46419649 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45534 BRD-K46419649 HT29 10 uM 6 h 0.0 0.0 0.0 0.38 1.35 1.72
45699 BRD-K46419649 MCF??7.00 10 uM 24 h 0.19 0.77 0.0 -0.28 -0.96 0.42
46086 BRD-K46419649 NPC 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
46724 BRD-K46419649 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
90867 BRD-K46419649 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).