CMap Candidate Details

Structure:
CMap ID: C17278
Pert ID: BRD-K46604138
Compound Name: dapagliflozin
Targets: SLC5A2
MoA: Sodium/glucose cotransporter inhibitor
SMILES: CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)cc1
InchiKey: JVHXJTBJCFBINQ-MJCUULBUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125306 BRD-K46604138 HEK293 0.04 uM 24 h -0.24 -1.01 0.16 0.33 1.16 0.9
125352 BRD-K46604138 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125440 BRD-K46604138 MCF??7.00 3.33 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
125514 BRD-K46604138 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
133336 BRD-K46604138 A375 0.08 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
133360 BRD-K46604138 A549 0.03 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
133386 BRD-K46604138 HA1E 0.74 uM 24 h -0.29 -1.2 0.57 0.0 0.0 0.0
133451 BRD-K46604138 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133480 BRD-K46604138 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133512 BRD-K46604138 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
133549 BRD-K46604138 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
133579 BRD-K46604138 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133627 BRD-K46604138 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).