CMap Candidate Details

Structure:
CMap ID: C17432
Pert ID: BRD-K47105409
Compound Name: AG-490
Targets: JAK2; JAK3
MoA: JAK inhibitor; EGFR inhibitor; ErbB2 inhibitor
SMILES: Oc1ccc(cc1O)C=C(/C#N)C(=O)NCc1ccccc1
InchiKey: TUCIOBMMDDOEMM-RIYZIHGNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2887 BRD-K47105409 HA1E 10 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
3213 BRD-K47105409 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3512 BRD-K47105409 PC3 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
3811 BRD-K47105409 VCAP 10 uM 24 h -0.24 -1.01 0.17 0.27 0.96 0.33
44410 BRD-K47105409 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44975 BRD-K47105409 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45270 BRD-K47105409 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45539 BRD-K47105409 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45703 BRD-K47105409 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46090 BRD-K47105409 NPC 10 uM 24 h -0.27 -1.13 0.41 -0.37 -1.23 1.28
46406 BRD-K47105409 PHH 10 uM 24 h 0.29 1.2 0.42 0.0 0.0 0.0
96147 BRD-K47105409 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99573 BRD-K47105409 U2OS 15 uM 6 h 0.28 1.17 0.36 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).