CMap Candidate Details

Structure:
CMap ID: C17447
Pert ID: BRD-K47150025
Compound Name: KI-8751
Targets: KDR
MoA: KIT inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
InchiKey: LFKQSJNCVRGFCC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6882 BRD-K47150025 A375 10 uM 6 h -0.29 -1.2 0.57 -0.49 -1.65 15.65
7000 BRD-K47150025 A549 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.43 15.35
7448 BRD-K47150025 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7665 BRD-K47150025 HCC515 10 uM 6 h -0.23 -0.94 0.08 -0.38 -1.27 1.4
7871 BRD-K47150025 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8097 BRD-K47150025 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
8375 BRD-K47150025 PC3 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
8684 BRD-K47150025 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53453 BRD-K47150025 HEPG2 2.5 uM 6 h -0.19 -0.81 0.0 -0.3 -1.0 0.55
53515 BRD-K47150025 HUH7 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53668 BRD-K47150025 PHH 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).