CMap Candidate Details

Structure:
CMap ID: C17499
Pert ID: BRD-K47335880
Compound Name: GMX-1778
Targets: NAMPT
MoA: NAMPT inhibitor
SMILES: Clc1ccc(OCCCCCCN=C(NC#N)Nc2ccncc2)cc1
InchiKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9206 BRD-K47335880 A549 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9430 BRD-K47335880 AGS 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9734 BRD-K47335880 H1299 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9966 BRD-K47335880 HA1E 0.08 uM 24 h 0.18 0.74 0.0 -0.27 -0.89 0.27
10335 BRD-K47335880 HCC515 0.08 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
10522 BRD-K47335880 HCT116 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10790 BRD-K47335880 HEPG2 0.08 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
10977 BRD-K47335880 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11215 BRD-K47335880 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11494 BRD-K47335880 NCIH2073 0.08 uM 6 h -0.2 -0.84 0.01 0.0 0.0 0.0
12057 BRD-K47335880 NCIH596 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12798 BRD-K47335880 SW480 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13279 BRD-K47335880 U937 0.08 uM 6 h -0.18 -0.76 0.0 0.34 1.19 1.03
13624 BRD-K47335880 VCAP 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96867 BRD-K47335880 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96940 BRD-K47335880 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.45 -1.51 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).