CMap Candidate Details

Structure:
CMap ID: C01752
Pert ID: BRD-A71816415
Compound Name: pravastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CCC(C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)C12
InchiKey: TUZYXOIXSAXUGO-XYLZAPOUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4026 BRD-A71816415 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4317 BRD-A71816415 HCC515 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
4760 BRD-A71816415 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5008 BRD-A71816415 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.13 0.98
37098 BRD-A71816415 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37353 BRD-A71816415 A549 10 uM 6 h -0.32 -1.31 0.82 0.0 0.0 0.0
37542 BRD-A71816415 ASC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
38035 BRD-A71816415 HT29 10 uM 6 h -0.22 -0.9 0.04 -0.35 -1.17 1.12
38165 BRD-A71816415 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38387 BRD-A71816415 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100308 BRD-A71816415 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).