CMap Candidate Details

Structure:
CMap ID: C17612
Pert ID: BRD-K47642186
Compound Name: piclamilast
Targets: PDE4A; PDE4B; PDE4C; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
InchiKey: RRRUXBQSQLKHEL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125238 BRD-K47642186 A375 1.11 uM 24 h -0.28 -1.18 0.5 -0.37 -1.23 1.28
125278 BRD-K47642186 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125310 BRD-K47642186 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125397 BRD-K47642186 JURKAT 10 uM 24 h 0.31 1.31 0.75 0.24 0.84 0.13
125443 BRD-K47642186 MCF??7.00 3.33 uM 24 h -0.2 -0.81 0.0 -0.35 -1.18 1.14
125516 BRD-K47642186 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133361 BRD-K47642186 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133419 BRD-K47642186 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133452 BRD-K47642186 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
133515 BRD-K47642186 MCF10A 0.01 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
133552 BRD-K47642186 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133581 BRD-K47642186 PC3 0.01 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
133630 BRD-K47642186 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
136447 BRD-K47642186 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.43 1.51 2.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).