CMap Candidate Details

Structure:
CMap ID: C01767
Pert ID: BRD-A72309220
Compound Name: metergoline
Targets: HTR1A; HTR2A
MoA: Serotonin receptor antagonist; Dopamine receptor agonist
SMILES: CN1CC(CNC(=O)OCc2ccccc2)C[C@@H]2C1Cc1cn(C)c3cccc2c13
InchiKey: WZHJKEUHNJHDLS-STDCAVTESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126363 BRD-A72309220 A375 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
126381 BRD-A72309220 A549 10 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
126404 BRD-A72309220 HA1E 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
126440 BRD-A72309220 HEK293 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.56
126495 BRD-A72309220 HT29 10 uM 24 h 0.16 0.67 0.0 0.23 0.81 0.09
126522 BRD-A72309220 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126539 BRD-A72309220 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126604 BRD-A72309220 YAPC 10 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
134429 BRD-A72309220 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134506 BRD-A72309220 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134599 BRD-A72309220 MDAMB231 0.25 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
134627 BRD-A72309220 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).