CMap Candidate Details

Structure:
CMap ID: C17713
Pert ID: BRD-K47936004
Compound Name: piribedil
Targets: ADRA2A; DRD2; DRD3
MoA: Dopamine receptor agonist
SMILES: C(N1CCN(CC1)c1ncccn1)c1ccc2OCOc2c1
InchiKey: OQDPVLVUJFGPGQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6884 BRD-K47936004 A375 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.88
7161 BRD-K47936004 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25376 BRD-K47936004 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91134 BRD-K47936004 HUH7 12 uM 72 h 0.0 0.0 0.0 -0.23 -0.79 0.1
99585 BRD-K47936004 U2OS 10 uM 6 h 0.0 0.0 0.0 0.22 0.78 0.07
125680 BRD-K47936004 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125750 BRD-K47936004 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125785 BRD-K47936004 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125833 BRD-K47936004 MCF??7.00 1.11 uM 24 h 0.21 0.87 0.01 -0.3 -1.0 0.55
125900 BRD-K47936004 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125948 BRD-K47936004 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133711 BRD-K47936004 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133741 BRD-K47936004 HEK293 0.74 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
133807 BRD-K47936004 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133866 BRD-K47936004 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.05
133924 BRD-K47936004 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
133953 BRD-K47936004 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).