CMap Candidate Details

Structure:
CMap ID: C17728
Pert ID: BRD-K47983010
Compound Name: BX-795
Targets: PDK1; PDPK1
MoA: IKK inhibitor
SMILES: Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1
InchiKey: VAVXGGRQQJZYBL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9431 BRD-K47983010 AGS 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.92
9735 BRD-K47983010 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10523 BRD-K47983010 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11216 BRD-K47983010 MCF??7.00 10 uM 24 h 0.24 0.98 0.09 -0.28 -0.94 0.37
11495 BRD-K47983010 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12058 BRD-K47983010 NCIH596 10 uM 6 h -0.25 -1.03 0.19 0.0 0.0 0.0
12607 BRD-K47983010 PC3 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.64
12799 BRD-K47983010 SW480 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.88
13280 BRD-K47983010 U937 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.96
13625 BRD-K47983010 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94448 BRD-K47983010 A549 10 uM 24 h -0.29 -1.2 0.57 -0.34 -1.16 1.09
94513 BRD-K47983010 ASC 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
94552 BRD-K47983010 CD34 10 uM 24 h -0.33 -1.37 1.08 0.0 0.0 0.0
94599 BRD-K47983010 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.48 -1.6 15.65
94643 BRD-K47983010 HEK293 10 uM 24 h -0.26 -1.07 0.27 0.35 1.25 1.29
94693 BRD-K47983010 HELA 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
94747 BRD-K47983010 HME1 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.77
94839 BRD-K47983010 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.36 2.02
94892 BRD-K47983010 JURKAT 10 uM 24 h -0.24 -1.01 0.17 -0.23 -0.77 0.08
94938 BRD-K47983010 MCF10A 3.33 uM 24 h -0.22 -0.9 0.04 0.24 0.85 0.14
95018 BRD-K47983010 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95090 BRD-K47983010 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95165 BRD-K47983010 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95210 BRD-K47983010 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95275 BRD-K47983010 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
115647 BRD-K47983010 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115722 BRD-K47983010 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115810 BRD-K47983010 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115857 BRD-K47983010 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).