CMap Candidate Details

Structure:
CMap ID: C17797
Pert ID: BRD-K48168960
Compound Name: propylthiouracil
Targets: DIO1; TPO
MoA: Thyroid peroxidase inhibitor
SMILES: CCCc1cc(=O)[nH]c(=S)[nH]1
InchiKey: KNAHARQHSZJURB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50016 BRD-K48168960 A549 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.36 2.02
50369 BRD-K48168960 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.2 -0.67 0.02
99588 BRD-K48168960 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121572 BRD-K48168960 A375 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
121617 BRD-K48168960 HA1E 0.37 uM 24 h -0.2 -0.83 0.0 0.33 1.18 1.01
121649 BRD-K48168960 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121666 BRD-K48168960 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129668 BRD-K48168960 MCF??7.00 0.74 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
129705 BRD-K48168960 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129738 BRD-K48168960 YAPC 0.74 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).