CMap Candidate Details

Structure:
CMap ID: C17808
Pert ID: BRD-K48195801
Compound Name: tecastemizole
Targets: HRH1
MoA: Histamine receptor antagonist
SMILES: Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1
InchiKey: SFOVDSLXFUGAIV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125258 BRD-K48195801 A549 1.11 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
125280 BRD-K48195801 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125315 BRD-K48195801 HEK293 0.04 uM 24 h 0.2 0.83 0.0 0.34 1.21 1.15
125398 BRD-K48195801 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125415 BRD-K48195801 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125447 BRD-K48195801 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.95
125519 BRD-K48195801 THP1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
125547 BRD-K48195801 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133341 BRD-K48195801 A375 2.22 uM 24 h -0.24 -0.99 0.13 -0.31 -1.04 0.67
133424 BRD-K48195801 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133457 BRD-K48195801 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133555 BRD-K48195801 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133583 BRD-K48195801 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).