CMap Candidate Details

Structure:
CMap ID: C17929
Pert ID: BRD-K48578705
Compound Name: methyldopa
Targets: ADRA2A; DDC
MoA: Adrenergic receptor agonist
SMILES: C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O
InchiKey: CJCSPKMFHVPWAR-JTQLQIEISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91220 BRD-K48578705 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
125595 BRD-K48578705 A375 0.125 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
125658 BRD-K48578705 HEK293 0.125 uM 24 h -0.26 -1.08 0.29 0.0 0.0 0.0
125679 BRD-K48578705 HELA 0.04 uM 24 h 0.26 1.07 0.19 0.42 1.49 2.25
125748 BRD-K48578705 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
125784 BRD-K48578705 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125946 BRD-K48578705 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133673 BRD-K48578705 A549 0.01 uM 24 h -0.31 -1.27 0.74 0.0 0.0 0.0
133710 BRD-K48578705 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.28 1.01 0.44
133806 BRD-K48578705 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
133865 BRD-K48578705 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
133891 BRD-K48578705 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.03
133923 BRD-K48578705 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133952 BRD-K48578705 PC3 2.22 uM 24 h -0.21 -0.86 0.01 -0.21 -0.71 0.03
133986 BRD-K48578705 THP1 0.01 uM 24 h -0.24 -1.01 0.17 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).