CMap Candidate Details

Structure:
CMap ID: C17977
Pert ID: BRD-K48722833
Compound Name: iloperidone
Targets: DRD2; HTR1A; HTR2A; HTR6; HTR7
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O
InchiKey: XMXHEBAFVSFQEX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33565 BRD-K48722833 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34117 BRD-K48722833 ASC 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.53
34632 BRD-K48722833 HCC515 10 uM 6 h 0.21 0.89 0.02 0.0 0.0 0.0
34897 BRD-K48722833 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.37 1.3 1.53
35156 BRD-K48722833 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35393 BRD-K48722833 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35792 BRD-K48722833 NPC 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
36086 BRD-K48722833 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36277 BRD-K48722833 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36575 BRD-K48722833 SKB 10 uM 24 h 0.23 0.97 0.08 0.24 0.86 0.15
36827 BRD-K48722833 VCAP 10 uM 24 h 0.0 0.0 0.0 0.43 1.52 2.28
96149 BRD-K48722833 A549 10 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).