CMap Candidate Details

Structure:
CMap ID: C18031
Pert ID: BRD-K48892307
Compound Name: sasapyrine
Targets: PTGS1
MoA: NFKB pathway inhibitor
SMILES: OC(=O)c1ccccc1OC(=O)c1ccccc1O
InchiKey: WVYADZUPLLSGPU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125596 BRD-K48892307 A375 0.125 uM 24 h 0.32 1.35 0.94 0.3 1.07 0.63
125661 BRD-K48892307 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
125682 BRD-K48892307 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125701 BRD-K48892307 HT29 3.33 uM 24 h 0.17 0.71 0.0 0.0 0.0 0.0
125753 BRD-K48892307 HUVEC 1.11 uM 24 h -0.3 -1.24 0.64 -0.33 -1.1 0.87
125787 BRD-K48892307 JURKAT 0.37 uM 24 h 0.27 1.11 0.25 -0.35 -1.16 1.11
125901 BRD-K48892307 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125951 BRD-K48892307 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133675 BRD-K48892307 A549 2.22 uM 24 h -0.28 -1.18 0.51 0.3 1.06 0.59
133713 BRD-K48892307 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
133868 BRD-K48892307 MCF10A 0.03 uM 24 h 0.22 0.9 0.02 -0.24 -0.8 0.12
133894 BRD-K48892307 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133926 BRD-K48892307 MDAMB231 0.08 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
133956 BRD-K48892307 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).