CMap Candidate Details

Structure:
CMap ID: C18052
Pert ID: BRD-K48969316
Compound Name: BRD-K48969316
Targets: CASP1
MoA: Caspase inhibitor
SMILES: CC(C)(C)[C@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C#N
InchiKey: KENKPOUHXLJLEY-QANKJYHBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
21930 BRD-K48969316 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22295 BRD-K48969316 A549 10 uM 6 h 0.27 1.11 0.25 0.0 0.0 0.0
22504 BRD-K48969316 HA1E 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.16
22781 BRD-K48969316 HCC515 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
23072 BRD-K48969316 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.22 0.76 0.05
23370 BRD-K48969316 HT29 10 uM 6 h -0.25 -1.03 0.19 0.0 0.0 0.0
23588 BRD-K48969316 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
23866 BRD-K48969316 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24320 BRD-K48969316 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115110 BRD-K48969316 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).