CMap Candidate Details

Structure:
CMap ID: C18053
Pert ID: BRD-K48970916
Compound Name: danazol
Targets: ESR1; GNRHR
MoA: Estrogen receptor antagonist; Progesterone receptor agonist
SMILES: C[C@@]12CC[C@H]3[C@@H](CCC4=Cc5oncc5C[C@]34C)[C@@H]2CC[C@@]1(O)C#C
InchiKey: POZRVZJJTULAOH-LHZXLZLDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1754 BRD-K48970916 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1920 BRD-K48970916 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2397 BRD-K48970916 PC3 10 uM 6 h -0.24 -1.01 0.17 0.0 0.0 0.0
2480 BRD-K48970916 VCAP 10 uM 24 h 0.17 0.72 0.0 -0.36 -1.2 1.18
41776 BRD-K48970916 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41939 BRD-K48970916 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42374 BRD-K48970916 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42696 BRD-K48970916 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42998 BRD-K48970916 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43562 BRD-K48970916 NPC 10 uM 24 h 0.26 1.09 0.24 -0.39 -1.3 1.57
43862 BRD-K48970916 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50756 BRD-K48970916 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
91211 BRD-K48970916 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99596 BRD-K48970916 U2OS 6.66 uM 6 h 0.0 0.0 0.0 -0.34 -1.15 1.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).