CMap Candidate Details

Structure:
CMap ID: C18073
Pert ID: BRD-K49049886
Compound Name: CGS-15943
Targets: ADORA1; ADORA2A; ADORA2B
MoA: Adenosine receptor antagonist
SMILES: Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
InchiKey: MSJODEOZODDVGW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1173 BRD-K49049886 PC3 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
1257 BRD-K49049886 A549 10 uM 48 h 0.0 0.0 0.0 -0.38 -1.27 1.39
1402 BRD-K49049886 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.32 1.71
6765 BRD-K49049886 A375 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
7332 BRD-K49049886 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7671 BRD-K49049886 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
7876 BRD-K49049886 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8134 BRD-K49049886 MCF??7.00 10 uM 6 h 0.27 1.11 0.25 -0.33 -1.11 0.91
25377 BRD-K49049886 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53457 BRD-K49049886 HEPG2 2.5 uM 6 h 0.23 0.98 0.08 -0.27 -0.92 0.33
53516 BRD-K49049886 HUH7 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53671 BRD-K49049886 PHH 10 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
97465 BRD-K49049886 NKDBA 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).