CMap Candidate Details

Structure:
CMap ID: C01808
Pert ID: BRD-A73908300
Compound Name: EX-527
Targets: SIRT1
MoA: SIRT inhibitor
SMILES: NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
InchiKey: FUZYTVDVLBBXDL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91366 BRD-A73908300 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98849 BRD-A73908300 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99120 BRD-A73908300 NPC 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
127355 BRD-A73908300 A375 10 uM 24 h -0.23 -0.95 0.09 0.29 1.03 0.52
127395 BRD-A73908300 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127427 BRD-A73908300 HA1E 0.125 uM 24 h -0.25 -1.03 0.2 -0.32 -1.07 0.76
127466 BRD-A73908300 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127518 BRD-A73908300 JURKAT 3.33 uM 24 h 0.27 1.11 0.25 -0.27 -0.89 0.27
127557 BRD-A73908300 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127610 BRD-A73908300 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127688 BRD-A73908300 YAPC 10 uM 24 h -0.18 -0.73 0.0 0.3 1.05 0.58
135405 BRD-A73908300 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135472 BRD-A73908300 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135499 BRD-A73908300 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).