CMap Candidate Details

Structure:
CMap ID: C18081
Pert ID: BRD-K49071277
Compound Name: securinine
Targets: GABRA1
MoA: TP53 activator; GABA receptor antagonist
SMILES: O=C1O[C@@]23C[C@@H](C=CC2=C1)N1CCCC[C@H]31
InchiKey: SWZMSZQQJRKFBP-WZRBSPASSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1009 BRD-K49071277 CD34 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1047 BRD-K49071277 HL60 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1079 BRD-K49071277 PC3 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1104 BRD-K49071277 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).