CMap Candidate Details

Structure:
CMap ID: C18083
Pert ID: BRD-K49075727
Compound Name: nintedanib
Targets: FGFR1; FGFR3; FLT1; FLT4; KDR; PDGFRA; PDGFRB
MoA: FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: COC(=O)c1ccc2c(NC(=O)C2=C(/Nc2ccc(cc2)N(C)C(=O)CN2CCN(C)CC2)c2ccccc2)c1
InchiKey: XZXHXSATPCNXJR-ZIADKAODSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91878 BRD-K49075727 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.49 1.73 2.59
92409 BRD-K49075727 A375 0.12 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
92434 BRD-K49075727 A549 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.2
92464 BRD-K49075727 BT20 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92534 BRD-K49075727 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92579 BRD-K49075727 HS578T 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92668 BRD-K49075727 LNCAP 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92734 BRD-K49075727 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92772 BRD-K49075727 MDAMB231 10 uM 24 h -0.2 -0.81 0.0 0.26 0.9 0.23
92852 BRD-K49075727 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
125325 BRD-K49075727 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125357 BRD-K49075727 HELA 10 uM 24 h -0.25 -1.06 0.24 0.32 1.15 0.87
125380 BRD-K49075727 HT29 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.59 0.0
125406 BRD-K49075727 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125527 BRD-K49075727 THP1 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.02
125551 BRD-K49075727 YAPC 10 uM 24 h 0.0 0.0 0.0 0.42 1.49 2.26
133395 BRD-K49075727 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.42
133588 BRD-K49075727 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).