CMap Candidate Details

Structure:
CMap ID: C01809
Pert ID: BRD-A73909368
Compound Name: dactinomycin
Targets: POLR2A
MoA: RNA polymerase inhibitor
SMILES: CC(C)C1NC(=O)C(NC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C1=O)C(C)OC(=O)c1ccc(C)c2oc3c(C)c(=O)c(N)c(C(=O)OC(C)C4NC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C5CCCN5C(=O)C(NC4=O)C(C)C)c3nc12
InchiKey: QKRYGAZNLBVXHK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4027 BRD-A73909368 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4529 BRD-A73909368 HCC515 10 uM 6 h 0.0 0.0 0.0 0.38 1.34 1.72
4761 BRD-A73909368 PC3 10 uM 6 h 0.0 0.0 0.0 0.28 1.0 0.43
5009 BRD-A73909368 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37100 BRD-A73909368 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37251 BRD-A73909368 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
37546 BRD-A73909368 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37850 BRD-A73909368 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38037 BRD-A73909368 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38167 BRD-A73909368 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38661 BRD-A73909368 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).