CMap Candidate Details

Structure:
CMap ID: C18096
Pert ID: BRD-K49111258
Compound Name: prazosin
Targets: ADRA1D; ADRA1B; ADRA1A; ADRA2A; ADRA2B; ADRA2C
MoA: Adrenergic receptor antagonist
SMILES: COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
InchiKey: IENZQIKPVFGBNW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4118 BRD-K49111258 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4440 BRD-K49111258 HCC515 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
24584 BRD-K49111258 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25378 BRD-K49111258 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37678 BRD-K49111258 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37913 BRD-K49111258 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38502 BRD-K49111258 NPC 10 uM 24 h -0.2 -0.85 0.01 -0.26 -0.88 0.25
38737 BRD-K49111258 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52170 BRD-K49111258 MCF??7.00 10 uM 6 h -0.21 -0.89 0.03 0.3 1.07 0.63
91013 BRD-K49111258 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99598 BRD-K49111258 U2OS 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124571 BRD-K49111258 A375 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
124651 BRD-K49111258 HELA 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
124784 BRD-K49111258 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124827 BRD-K49111258 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124908 BRD-K49111258 YAPC 10 uM 24 h 0.26 1.1 0.24 0.35 1.22 1.15
132742 BRD-K49111258 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132806 BRD-K49111258 HT29 0.25 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
132827 BRD-K49111258 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132860 BRD-K49111258 MCF10A 2.22 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
132926 BRD-K49111258 THP1 0.03 uM 24 h -0.28 -1.15 0.44 -0.32 -1.08 0.8
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).