CMap Candidate Details

Structure:
CMap ID: C18149
Pert ID: BRD-K49328571
Compound Name: dasatinib
Targets: EPHA2; ABL1; FYN; KIT; LCK; LYN; PDGFRB; BCR; SRC; YES1
MoA: KIT inhibitor; Src inhibitor; PDGFR inhibitor; Ephrin inhibitor; Abl kinase inhibitor; Tyrosine kinase inhibitor
SMILES: Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
InchiKey: ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1296 BRD-K49328571 MCF??7.00 1.11 uM 48 h 0.0 0.0 0.0 -0.25 -0.85 0.2
33041 BRD-K49328571 SKB 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
33296 BRD-K49328571 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87305 BRD-K49328571 BJAB 10 uM 3 h 0.23 0.94 0.06 0.0 0.0 0.0
87356 BRD-K49328571 HBL1 10 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
87406 BRD-K49328571 K562 0.01 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
87454 BRD-K49328571 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87523 BRD-K49328571 MINO 0.66 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
87558 BRD-K49328571 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87608 BRD-K49328571 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87659 BRD-K49328571 OCILY19 2.5 uM 24 h -0.19 -0.78 0.0 -0.46 -1.56 15.65
87710 BRD-K49328571 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87757 BRD-K49328571 SKMEL5 10 uM 24 h 0.23 0.98 0.09 0.37 1.3 1.59
87804 BRD-K49328571 THP1 2.5 uM 3 h -0.26 -1.09 0.32 -0.38 -1.29 1.53
87869 BRD-K49328571 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90838 BRD-K49328571 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91345 BRD-K49328571 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
91509 BRD-K49328571 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91774 BRD-K49328571 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.28 0.97 0.36
91983 BRD-K49328571 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92155 BRD-K49328571 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92696 BRD-K49328571 LNCAP 3.33 uM 3 h 0.22 0.91 0.03 0.0 0.0 0.0
92790 BRD-K49328571 MDAMB231 3.33 uM 3 h 0.0 0.0 0.0 -0.29 -0.98 0.49
92807 BRD-K49328571 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93122 BRD-K49328571 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93217 BRD-K49328571 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
93482 BRD-K49328571 SKL 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93709 BRD-K49328571 CD34 10 uM 24 h -0.24 -1.0 0.15 -0.3 -1.01 0.57
93755 BRD-K49328571 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94020 BRD-K49328571 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94100 BRD-K49328571 NEU 0.37 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
94173 BRD-K49328571 NPC 0.12 uM 24 h -0.27 -1.12 0.38 -0.28 -0.94 0.39
94234 BRD-K49328571 SHSY5Y 0.04 uM 24 h -0.31 -1.27 0.74 0.0 0.0 0.0
94479 BRD-K49328571 ASC 0.04 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
94594 BRD-K49328571 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94740 BRD-K49328571 HME1 1.11 uM 24 h -0.27 -1.11 0.37 -0.37 -1.23 1.28
94789 BRD-K49328571 HT29 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95434 BRD-K49328571 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.28 -0.93 0.35
97256 BRD-K49328571 HAP1 3.33 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
115805 BRD-K49328571 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125263 BRD-K49328571 A549 10 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
125327 BRD-K49328571 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
125552 BRD-K49328571 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).