CMap Candidate Details

Structure:
CMap ID: C18158
Pert ID: BRD-K49350383
Compound Name: thioguanine
Targets: IMPDH1; IMPDH2
MoA: Purine antagonist
SMILES: Nc1nc2nc[nH]c2c(=S)[nH]1
InchiKey: WYWHKKSPHMUBEB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125262 BRD-K49350383 A549 10 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
125284 BRD-K49350383 HA1E 10 uM 24 h -0.18 -0.73 0.0 0.0 0.0 0.0
125324 BRD-K49350383 HEK293 3.33 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
125356 BRD-K49350383 HELA 0.125 uM 24 h 0.21 0.9 0.02 -0.28 -0.94 0.36
125379 BRD-K49350383 HT29 3.33 uM 24 h -0.29 -1.22 0.61 -0.27 -0.9 0.28
125405 BRD-K49350383 JURKAT 3.33 uM 24 h -0.16 -0.68 0.0 0.0 0.0 0.0
125419 BRD-K49350383 MCF10A 10 uM 24 h 0.25 1.02 0.13 -0.35 -1.17 1.12
125453 BRD-K49350383 MCF??7.00 3.33 uM 24 h 0.27 1.12 0.26 -0.4 -1.34 1.85
125476 BRD-K49350383 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125526 BRD-K49350383 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.18 0.65 0.0
133346 BRD-K49350383 A375 0.25 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
133587 BRD-K49350383 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133639 BRD-K49350383 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).