CMap Candidate Details

Structure:
CMap ID: C18188
Pert ID: BRD-K49456190
Compound Name: prima-1-met
Targets: TP53
MoA: Thioredoxin inhibitor
SMILES: COC[C@]1(CO)[N@@]2CC[C@@H](CC2)C1=O
InchiKey: BGBNULCRKBVAKL-JTQLQIEISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8946 BRD-K49456190 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9736 BRD-K49456190 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9969 BRD-K49456190 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
10526 BRD-K49456190 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11219 BRD-K49456190 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11774 BRD-K49456190 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12060 BRD-K49456190 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12326 BRD-K49456190 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.24
12801 BRD-K49456190 SW480 10 uM 6 h 0.25 1.03 0.13 0.0 0.0 0.0
13070 BRD-K49456190 THP1 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
13284 BRD-K49456190 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13628 BRD-K49456190 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115989 BRD-K49456190 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116071 BRD-K49456190 HCC515 1.11 uM 24 h -0.28 -1.16 0.46 0.0 0.0 0.0
116114 BRD-K49456190 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116160 BRD-K49456190 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
116240 BRD-K49456190 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).