CMap Candidate Details

Structure:
CMap ID: C18295
Pert ID: BRD-K49807096
Compound Name: benazepril
Targets: ACE
MoA: Angiotensin converting enzyme inhibitor
SMILES: CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O
InchiKey: XPCFTKFZXHTYIP-PMACEKPBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25382 BRD-K49807096 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95392 BRD-K49807096 U2OS 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125245 BRD-K49807096 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125331 BRD-K49807096 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
125381 BRD-K49807096 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125458 BRD-K49807096 MCF??7.00 0.37 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
125501 BRD-K49807096 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125529 BRD-K49807096 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125554 BRD-K49807096 YAPC 0.04 uM 24 h 0.24 1.01 0.12 -0.4 -1.34 1.85
133370 BRD-K49807096 A549 2.22 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
133399 BRD-K49807096 HA1E 0.01 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
133433 BRD-K49807096 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133490 BRD-K49807096 JURKAT 2.22 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
133527 BRD-K49807096 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133566 BRD-K49807096 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).