CMap Candidate Details

Structure:
CMap ID: C18298
Pert ID: BRD-K49810818
Compound Name: sorafenib
Targets: FGFR1; FLT1; FLT3; FLT4; KDR; KIT; DDR2; PDGFRB; RAF1; RET; BRAF
MoA: KIT inhibitor; RAF inhibitor; FLT3 inhibitor; PDGFR inhibitor; VEGFR inhibitor; RET tyrosine kinase inhibitor
SMILES: CNC(=O)c1cccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1
InchiKey: CGFGJVMEGKQFPL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29866 BRD-K49810818 A375 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
30203 BRD-K49810818 A549 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
30459 BRD-K49810818 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30763 BRD-K49810818 HA1E 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.48
31056 BRD-K49810818 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.58
31362 BRD-K49810818 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31687 BRD-K49810818 HT29 10 uM 6 h 0.0 0.0 0.0 0.42 1.48 2.25
32036 BRD-K49810818 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32188 BRD-K49810818 NEU 10 uM 24 h 0.25 1.06 0.18 -0.36 -1.21 1.24
32441 BRD-K49810818 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32784 BRD-K49810818 PC3 10 uM 6 h 0.0 0.0 0.0 -0.45 -1.53 15.35
33042 BRD-K49810818 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33297 BRD-K49810818 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
91510 BRD-K49810818 BT20 10 uM 24 h 0.18 0.76 0.0 -0.32 -1.08 0.8
91576 BRD-K49810818 HS578T 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91623 BRD-K49810818 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91710 BRD-K49810818 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91726 BRD-K49810818 SKBR3 10 uM 24 h 0.2 0.82 0.0 0.24 0.86 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).