CMap Candidate Details

Structure:
CMap ID: C01837
Pert ID: BRD-A75172220
Compound Name: hydrocortisone
Targets: NR3C1
MoA: Glucocorticoid receptor agonist
SMILES: C[C@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C1CC[C@]2(O)C(=O)CO
InchiKey: JYGXADMDTFJGBT-YDAVOWJHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4319 BRD-A75172220 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
4863 BRD-A75172220 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37547 BRD-A75172220 ASC 10 uM 24 h -0.29 -1.21 0.6 -0.23 -0.79 0.1
37851 BRD-A75172220 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38391 BRD-A75172220 NPC 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
90609 BRD-A75172220 HCT116 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90677 BRD-A75172220 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
98042 BRD-A75172220 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98097 BRD-A75172220 P1A82 1.11 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
127015 BRD-A75172220 A375 1.11 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
127134 BRD-A75172220 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127161 BRD-A75172220 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127234 BRD-A75172220 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.19
127276 BRD-A75172220 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135038 BRD-A75172220 A549 0.25 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
135080 BRD-A75172220 HA1E 0.74 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
135104 BRD-A75172220 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135129 BRD-A75172220 HELA 0.25 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
135257 BRD-A75172220 MDAMB231 0.74 uM 24 h -0.26 -1.07 0.26 -0.31 -1.03 0.64
135325 BRD-A75172220 YAPC 0.74 uM 24 h -0.28 -1.15 0.44 0.39 1.38 2.17
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).