CMap Candidate Details

Structure:
CMap ID: C18397
Pert ID: BRD-K50128260
Compound Name: sildenafil
Targets: PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: CCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
InchiKey: BNRNXUUZRGQAQC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8947 BRD-K50128260 A375 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9434 BRD-K50128260 AGS 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9737 BRD-K50128260 H1299 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10059 BRD-K50128260 HA1E 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10115 BRD-K50128260 HCC515 150 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
10527 BRD-K50128260 HCT116 150 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.71
10794 BRD-K50128260 HEPG2 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11054 BRD-K50128260 HT29 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11499 BRD-K50128260 NCIH2073 150 uM 6 h 0.22 0.91 0.03 0.0 0.0 0.0
12061 BRD-K50128260 NCIH596 150 uM 6 h -0.21 -0.89 0.04 0.0 0.0 0.0
12430 BRD-K50128260 PC3 150 uM 24 h -0.21 -0.86 0.01 0.0 0.0 0.0
12802 BRD-K50128260 SW480 150 uM 6 h 0.2 0.84 0.0 0.0 0.0 0.0
12929 BRD-K50128260 THP1 150 uM 6 h 0.19 0.8 0.0 0.0 0.0 0.0
13285 BRD-K50128260 U937 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13479 BRD-K50128260 VCAP 150 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.36
90531 BRD-K50128260 A549 0.125 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.18
90549 BRD-K50128260 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).