CMap Candidate Details

Structure:
CMap ID: C18405
Pert ID: BRD-K50140147
Compound Name: NVP-TAE684
Targets: ALK
MoA: ALK inhibitor
SMILES: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
InchiKey: QQWUGDVOUVUTOY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
64 BRD-K50140147 BJAB 10 uM 4 h 0.28 1.17 0.36 0.26 0.93 0.27
97 BRD-K50140147 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.04
131 BRD-K50140147 K562 10 uM 24 h 0.2 0.82 0.0 -0.25 -0.84 0.17
188 BRD-K50140147 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
228 BRD-K50140147 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
267 BRD-K50140147 OCILY10 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
315 BRD-K50140147 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
342 BRD-K50140147 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
386 BRD-K50140147 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
427 BRD-K50140147 THP1 10 uM 4 h -0.25 -1.02 0.19 0.24 0.86 0.16
467 BRD-K50140147 TMD8 10 uM 4 h 0.25 1.04 0.14 0.0 0.0 0.0
30461 BRD-K50140147 ASC 10 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
30764 BRD-K50140147 HA1E 10 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.76
33656 BRD-K50140147 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34636 BRD-K50140147 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34901 BRD-K50140147 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
35158 BRD-K50140147 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35578 BRD-K50140147 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35795 BRD-K50140147 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36280 BRD-K50140147 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36578 BRD-K50140147 SKB 10 uM 24 h -0.2 -0.83 0.0 -0.29 -0.97 0.45
36974 BRD-K50140147 VCAP 10 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
91511 BRD-K50140147 BT20 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91654 BRD-K50140147 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
91732 BRD-K50140147 SKBR3 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
92563 BRD-K50140147 HME1 3.33 uM 3 h 0.0 0.0 0.0 -0.4 -1.33 1.75
92587 BRD-K50140147 HS578T 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92697 BRD-K50140147 LNCAP 10 uM 3 h 0.0 0.0 0.0 0.31 1.1 0.68
92743 BRD-K50140147 MCF10A 0.04 uM 3 h -0.22 -0.92 0.06 -0.2 -0.66 0.01
92777 BRD-K50140147 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92811 BRD-K50140147 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
117733 BRD-K50140147 A549 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.5
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).