CMap Candidate Details

Structure:
CMap ID: C01843
Pert ID: BRD-A75409952
Compound Name: wortmannin
Targets: PIK3CA; PIK3CG; PLK1
MoA: PI3K inhibitor
SMILES: COCC1OC(=O)c2coc3c2C1(C)C1=C(C2CCC(=O)C2(C)CC1OC(C)=O)C3=O
InchiKey: QDLHCMPXEPAAMD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
136 BRD-A75409952 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
194 BRD-A75409952 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
233 BRD-A75409952 NALM6 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.02
273 BRD-A75409952 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
317 BRD-A75409952 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
430 BRD-A75409952 THP1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
518 BRD-A75409952 BJAB 2.5 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
565 BRD-A75409952 HBL1 2.5 uM 4 h 0.18 0.76 0.0 0.32 1.14 0.87
702 BRD-A75409952 MINO 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
843 BRD-A75409952 OCILY3 10 uM 4 h 0.0 0.0 0.0 -0.44 -1.47 15.35
892 BRD-A75409952 SKMEL5 0.66 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
948 BRD-A75409952 TMD8 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
979 BRD-A75409952 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
1034 BRD-A75409952 HL60 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1092 BRD-A75409952 U937 10 uM 24 h 0.0 0.0 0.0 0.24 0.87 0.17
1134 BRD-A75409952 PC3 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4530 BRD-A75409952 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9307 BRD-A75409952 AGS 10 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.34
9612 BRD-A75409952 H1299 10 uM 6 h -0.2 -0.84 0.0 -0.22 -0.75 0.07
11362 BRD-A75409952 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
11669 BRD-A75409952 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11934 BRD-A75409952 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
12684 BRD-A75409952 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37549 BRD-A75409952 ASC 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
38887 BRD-A75409952 SKB 10 uM 24 h -0.2 -0.82 0.0 -0.29 -0.97 0.46
53063 BRD-A75409952 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53554 BRD-A75409952 HUH7 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
53712 BRD-A75409952 PHH 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
59516 BRD-A75409952 VCAP 10 uM 6 h 0.27 1.14 0.32 0.0 0.0 0.0
75178 BRD-A75409952 MCF??7.00 10 uM 24 h -0.32 -1.34 0.98 -0.31 -1.04 0.67
77455 BRD-A75409952 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
78987 BRD-A75409952 A549 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
90593 BRD-A75409952 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90731 BRD-A75409952 NOMO1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97560 BRD-A75409952 NKDBA 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
98199 BRD-A75409952 NPC 10 uM 6 h -0.23 -0.94 0.08 -0.24 -0.81 0.13
98465 BRD-A75409952 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
106414 BRD-A75409952 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115852 BRD-A75409952 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116485 BRD-A75409952 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118136 BRD-A75409952 HA1E 10 uM 24 h -0.2 -0.84 0.01 -0.27 -0.92 0.33
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).