CMap Candidate Details

Structure:
CMap ID: C01847
Pert ID: BRD-A75478957
Compound Name: PD-166793
Targets: MMP2; MMP3; MMP13
MoA: Collagenase inhibitor; Metalloproteinase inhibitor
SMILES: CC(C)C(NS(=O)(=O)c1ccc(cc1)c2ccc(Br)cc2)C(=O)O
InchiKey: GJOCABIDMCKCEG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1511 BRD-A75478957 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.04
2051 BRD-A75478957 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2283 BRD-A75478957 PC3 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
2768 BRD-A75478957 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
39064 BRD-A75478957 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39409 BRD-A75478957 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39590 BRD-A75478957 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39910 BRD-A75478957 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40195 BRD-A75478957 HT29 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.25 1.35
40577 BRD-A75478957 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.54
40714 BRD-A75478957 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41014 BRD-A75478957 NPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
41337 BRD-A75478957 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100320 BRD-A75478957 U2OS 10 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.41
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).