CMap Candidate Details

Structure:
CMap ID: C18492
Pert ID: BRD-K50398167
Compound Name: meclofenamic-acid
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor; Prostanoid receptor antagonist
SMILES: Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InchiKey: SBDNJUWAMKYJOX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3375 BRD-K50398167 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3821 BRD-K50398167 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44981 BRD-K50398167 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45277 BRD-K50398167 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
46097 BRD-K50398167 NPC 10 uM 24 h -0.28 -1.16 0.45 -0.21 -0.72 0.04
46736 BRD-K50398167 SKB 10 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
99616 BRD-K50398167 U2OS 10 uM 6 h -0.3 -1.27 0.74 -0.24 -0.81 0.13
125250 BRD-K50398167 A375 0.125 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
125339 BRD-K50398167 HEK293 0.125 uM 24 h 0.26 1.1 0.24 -0.24 -0.8 0.12
125409 BRD-K50398167 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125425 BRD-K50398167 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
125465 BRD-K50398167 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125506 BRD-K50398167 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.25
133375 BRD-K50398167 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133404 BRD-K50398167 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133440 BRD-K50398167 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.3 1.04 0.56
133468 BRD-K50398167 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
133573 BRD-K50398167 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
133616 BRD-K50398167 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133650 BRD-K50398167 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).