CMap Candidate Details

Structure:
CMap ID: C18500
Pert ID: BRD-K50422030
Compound Name: clomethiazole
Targets: GABRA1
MoA: GABA receptor modulator; GABA receptor antagonist
SMILES: Cc1ncsc1CCCl
InchiKey: PCLITLDOTJTVDJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3222 BRD-K50422030 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
3822 BRD-K50422030 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42379 BRD-K50422030 ASC 10 uM 24 h -0.17 -0.7 0.0 -0.31 -1.05 0.71
42700 BRD-K50422030 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43567 BRD-K50422030 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43867 BRD-K50422030 PHH 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
44128 BRD-K50422030 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97193 BRD-K50422030 PC3 10 uM 24 h -0.27 -1.11 0.36 -0.24 -0.79 0.11
99619 BRD-K50422030 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
125247 BRD-K50422030 A375 0.125 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
125286 BRD-K50422030 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125336 BRD-K50422030 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
125463 BRD-K50422030 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
125531 BRD-K50422030 THP1 10 uM 24 h -0.27 -1.13 0.41 0.35 1.24 1.28
133374 BRD-K50422030 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133439 BRD-K50422030 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
133466 BRD-K50422030 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
133495 BRD-K50422030 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133530 BRD-K50422030 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133570 BRD-K50422030 MDAMB231 0.25 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
133647 BRD-K50422030 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).