CMap Candidate Details

Structure:
CMap ID: C18572
Pert ID: BRD-K50691590
Compound Name: bortezomib
Targets: PSMB1; PSMB2; PSMB5
MoA: Proteasome inhibitor; NFKB pathway inhibitor
SMILES: CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1=CNC=CN1)B(O)O
InchiKey: RFGAQTOFZHCFHG-NVXWUHKLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
119897 BRD-K50691590 HCC515 3.33 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
119908 BRD-K50691590 MCF??7.00 0.04 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.01
119920 BRD-K50691590 PC3 0.125 uM 6 h 0.0 0.0 0.0 -0.41 -1.37 2.02
120948 BRD-K50691590 HEK293 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126510 BRD-K50691590 MCF10A 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127809 BRD-K50691590 HA1E 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128859 BRD-K50691590 YAPC 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129398 BRD-K50691590 A375 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134202 BRD-K50691590 HUVEC 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135142 BRD-K50691590 HT29 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135263 BRD-K50691590 MDAMB231 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135343 BRD-K50691590 A549 20 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
135363 BRD-K50691590 HELA 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).