CMap Candidate Details

Structure:
CMap ID: C18585
Pert ID: BRD-K50720187
Compound Name: flupirtine
Targets: KCNQ1; KCNQ2
MoA: Glutamate receptor antagonist
SMILES: CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N
InchiKey: JUUFBMODXQKSTD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33617 BRD-K50720187 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34122 BRD-K50720187 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34377 BRD-K50720187 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34638 BRD-K50720187 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34903 BRD-K50720187 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35160 BRD-K50720187 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35324 BRD-K50720187 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35580 BRD-K50720187 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35797 BRD-K50720187 NPC 10 uM 24 h 0.0 0.0 0.0 -0.47 -1.6 15.65
35967 BRD-K50720187 PC3 10 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
36581 BRD-K50720187 SKB 10 uM 24 h -0.24 -1.0 0.14 -0.32 -1.09 0.84
36975 BRD-K50720187 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96153 BRD-K50720187 A549 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).