CMap Candidate Details

Structure:
CMap ID: C01864
Pert ID: BRD-A76019558
Compound Name: ketoconazole
Targets: CYP19A1; AR
MoA: Sterol demethylase inhibitor
SMILES: CC(=O)N1CCN(CC1)c2ccc(OCC3COC(Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2
InchiKey: XMAYWYJOQHXEEK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49777 BRD-A76019558 A375 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
50121 BRD-A76019558 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50471 BRD-A76019558 HT29 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.63
50721 BRD-A76019558 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.31 1.08 0.67
50812 BRD-A76019558 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50989 BRD-A76019558 VCAP 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
96093 BRD-A76019558 A549 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).