CMap Candidate Details

Structure:
CMap ID: C18645
Pert ID: BRD-K50938287
Compound Name: sumatriptan
Targets: HTR1A; HTR1B; HTR1D; HTR1F
MoA: Serotonin receptor agonist
SMILES: CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InchiKey: KQKPFRSPSRPDEB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25517 BRD-K50938287 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
91324 BRD-K50938287 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
124774 BRD-K50938287 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
124822 BRD-K50938287 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124865 BRD-K50938287 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
132654 BRD-K50938287 A375 0.01 uM 24 h 0.25 1.04 0.16 -0.28 -0.93 0.35
132677 BRD-K50938287 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132710 BRD-K50938287 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
132735 BRD-K50938287 HEK293 0.01 uM 24 h -0.25 -1.06 0.24 0.0 0.0 0.0
132778 BRD-K50938287 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132803 BRD-K50938287 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132821 BRD-K50938287 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132852 BRD-K50938287 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132892 BRD-K50938287 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132939 BRD-K50938287 YAPC 0.01 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).