CMap Candidate Details

Structure:
CMap ID: C01866
Pert ID: BRD-A76093993
Compound Name: cromakalim
Targets: KCNJ8
MoA: Potassium channel activator
SMILES: CC1(C)Oc2ccc(C#N)cc2C(C1O)N3CCCC3=O
InchiKey: TVZCRIROJQEVOT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1512 BRD-A76093993 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.04
2052 BRD-A76093993 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2256 BRD-A76093993 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2584 BRD-A76093993 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39065 BRD-A76093993 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39281 BRD-A76093993 A549 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
39591 BRD-A76093993 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39911 BRD-A76093993 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.86
40196 BRD-A76093993 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.88
40578 BRD-A76093993 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
40715 BRD-A76093993 NEU 10 uM 24 h -0.32 -1.32 0.83 0.0 0.0 0.0
41015 BRD-A76093993 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41338 BRD-A76093993 SKB 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
100325 BRD-A76093993 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).