CMap Candidate Details

Structure:
CMap ID: C18675
Pert ID: BRD-K51033547
Compound Name: tramadol
Targets: OPRM1; SLC6A2; SLC6A4
MoA: Opioid receptor agonist; Serotonin reuptake inhibitor; Norepinephrine reputake inhibitor
SMILES: COc1cccc(c1)[C@]1(O)CCCC[C@H]1CN(C)C
InchiKey: TVYLLZQTGLZFBW-GOEBONIOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4441 BRD-K51033547 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
4935 BRD-K51033547 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37395 BRD-K51033547 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37682 BRD-K51033547 ASC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
37917 BRD-K51033547 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38740 BRD-K51033547 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38967 BRD-K51033547 SKB 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
121622 BRD-K51033547 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.82
121692 BRD-K51033547 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129590 BRD-K51033547 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129617 BRD-K51033547 HELA 0.01 uM 24 h -0.37 -1.56 1.43 0.0 0.0 0.0
129647 BRD-K51033547 HT29 2.22 uM 24 h 0.3 1.24 0.53 -0.38 -1.27 1.4
129709 BRD-K51033547 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129743 BRD-K51033547 YAPC 0.03 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).