CMap Candidate Details
Structure:
| CMap ID: | C18679 |
| Pert ID: | BRD-K51040301 |
| Compound Name: | cobicistat |
| Targets: | CYP3A4 |
| MoA: | Cytochrome P450 inhibitor |
| SMILES: | CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1 |
| InchiKey: | ZCIGNRJZKPOIKD-CQXVEOKZSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 121621 | BRD-K51040301 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121668 | BRD-K51040301 | HT29 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.98 | 0.48 |
| 121715 | BRD-K51040301 | YAPC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129588 | BRD-K51040301 | A375 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.32 | 1.14 | 0.87 |
| 129614 | BRD-K51040301 | HELA | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129669 | BRD-K51040301 | MCF??7.00 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.44 | -1.47 | 15.35 |
| 129707 | BRD-K51040301 | PC3 | 0.74 uM | 24 h | -0.27 | -1.11 | 0.37 | -0.24 | -0.79 | 0.11 |