CMap Candidate Details

Structure:
CMap ID: C00187
Pert ID: BRD-A07395371
Compound Name: esmolol
Targets: ADRB1
MoA: Adrenergic receptor antagonist
SMILES: COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
InchiKey: AQNDDEOPVVGCPG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25464 BRD-A07395371 VCAP 10 uM 6 h 0.24 0.99 0.1 0.2 0.71 0.02
91483 BRD-A07395371 HUH7 12 uM 72 h 0.0 0.0 0.0 0.42 1.5 2.27
122554 BRD-A07395371 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122583 BRD-A07395371 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
122605 BRD-A07395371 HA1E 0.37 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
122640 BRD-A07395371 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122732 BRD-A07395371 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122799 BRD-A07395371 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122820 BRD-A07395371 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
130974 BRD-A07395371 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.77
131005 BRD-A07395371 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131054 BRD-A07395371 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131089 BRD-A07395371 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131127 BRD-A07395371 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).