CMap Candidate Details

Structure:
CMap ID: C01871
Pert ID: BRD-A76528577
Compound Name: vincristine
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CCC1(O)CC2CN(C1)CCc3c([nH]c4ccccc34)C(C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7C86CCN9CC=CC(CC)(C98)C(C(=O)OC)C7(O)C(=O)OC
InchiKey: KUSGVVPSWLLOSB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2972 BRD-A76528577 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3323 BRD-A76528577 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3451 BRD-A76528577 PC3 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.43
3701 BRD-A76528577 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39066 BRD-A76528577 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39410 BRD-A76528577 A549 10 uM 6 h 0.29 1.19 0.42 -0.33 -1.1 0.86
39592 BRD-A76528577 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39912 BRD-A76528577 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40197 BRD-A76528577 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40435 BRD-A76528577 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
40716 BRD-A76528577 NEU 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
41016 BRD-A76528577 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41339 BRD-A76528577 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).