CMap Candidate Details

Structure:
CMap ID: C18712
Pert ID: BRD-K51143828
Compound Name: lurasidone
Targets: HTR2A; HTR7; ADRA2A; ADRA2C; DRD2; HTR1A
MoA: Serotonin receptor antagonist; Dopamine receptor antagonist
SMILES: O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(CC1)c1nsc2ccccc12
InchiKey: PQXKDMSYBGKCJA-CVTJIBDQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1421 BRD-K51143828 NPC 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124269 BRD-K51143828 A375 10 uM 24 h 0.24 1.02 0.12 0.36 1.26 1.29
124294 BRD-K51143828 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124374 BRD-K51143828 HT29 10 uM 24 h 0.33 1.36 0.96 0.32 1.15 0.88
124395 BRD-K51143828 JURKAT 10 uM 24 h -0.34 -1.43 1.43 0.0 0.0 0.0
124474 BRD-K51143828 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132346 BRD-K51143828 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132405 BRD-K51143828 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132436 BRD-K51143828 HELA 0.74 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
132479 BRD-K51143828 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132514 BRD-K51143828 MCF??7.00 0.01 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
132565 BRD-K51143828 PC3 0.01 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
132582 BRD-K51143828 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132633 BRD-K51143828 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.46 -1.56 15.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).