CMap Candidate Details

Structure:
CMap ID: C18759
Pert ID: BRD-K51276371
Compound Name: aloisine
Targets: CDK2
MoA: CDK inhibitor; GSK-3 inhibitor; CFTR channel agonist
SMILES: CCCCc1c([nH]c2nccnc12)c3ccc(OC)cc3
InchiKey: WVMANZPBOBRWCB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1755 BRD-K51276371 HA1E 10 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
2105 BRD-K51276371 HCC515 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.15
2398 BRD-K51276371 PC3 10 uM 6 h 0.23 0.96 0.07 0.25 0.89 0.21
2639 BRD-K51276371 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41780 BRD-K51276371 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42101 BRD-K51276371 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42380 BRD-K51276371 ASC 10 uM 24 h -0.17 -0.7 0.0 0.31 1.11 0.71
42701 BRD-K51276371 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43003 BRD-K51276371 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43197 BRD-K51276371 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
43568 BRD-K51276371 NPC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
43868 BRD-K51276371 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44129 BRD-K51276371 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99626 BRD-K51276371 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).